Lecture 14: Transmission-disequilibrium test: Dichotomous traits

In the textbooks

• Sham: Section 4.7
• Lange: Section 4.7
• Ott: Section 13.5

Other references

• DJ Schaid (1999) Likelihoods and TDT for the case-parents design. Genet Epidemiol 16:250-260
• RS Spielman and WJ Ewens (1998) A sibship test for linkage in the presence of association: The sib transmission/disequilibrium test. Am J Hum Genet 62:450-458
• M Boehnke and CD Langefeld (1998) Genetic association mapping based on discordant sib pairs: The discordant-alleles test. Am J Hum Genet 62:950-961
• DJ Schaid and C Rowland (1998) Use of Parents, sibs, and unrelated controls for detection of associations between genetic markers and disease. Am J Hum Genet 63:1492-1506
• S Horvath and NM Laird (1998) A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am J Hum Genet 63:1886-1897
• BFJ Manly (1997) Randomization, bootstrap and Monte Carlo methods in biology, 2nd edition. Chapman & Hall, London.